Commentary on the famous Buddhist Sutra of the wise and the foolish (Mdzangs blun zhes bya baʼi mdo).

The objectives of this study were to develop a high-density chromosome bin map of homoeologous group 7 in hexaploid wheat, to identify gene distribution in these chromosomes, and to perform comparative studies of wheat with rice and barley. We mapped 2148 loci from 919 EST clones onto group 7 chromosomes of wheat. In the majority of cases the numbers of loci were significantly lower in the centromeric regions and tended to increase in the distal regions. The level of duplicated loci (...) in this group was 24% with most of these loci being localized toward the distal regions. One hundred nineteen EST probes that hybridized to three fragments and mapped to the three group 7 chromosomes were designated landmark probes and were used to construct a consensus homoeologous group 7 map. An additional 49 probes that mapped to 7AS, 7DS, and the ancestral translocated segment involving 7BS also were designated landmarks. Landmark probe orders and comparative maps of wheat, rice, and barley were produced on the basis of corresponding rice BAC/PAC and genetic markers that mapped on chromosomes 6 and 8 of rice. Identification of landmark ESTs and development of consensus maps may provide a framework of conserved coding regions predating the evolution of wheat genomes. (shrink)

A total of 1918 loci, detected by the hybridization of 938 expressed sequence tag unigenes from 26 Triticeae cDNA libraries, were mapped to wheat homoeologous group 4 chromosomes using a set of deletion, ditelosomic, and nulli-tetrasomic lines. The 1918 EST loci were not distributed uniformly among the three group 4 chromosomes; 41, 28, and 31% mapped to chromosomes 4A, 4B, and 4D, respectively. This pattern is in contrast to the cumulative results of EST mapping in all homoeologous groups, as reported (...) elsewhere, that found the highest proportion of loci mapped to the B genome. Sixty-five percent of these 1918 loci mapped to the long arms of homoeologous group 4 chromosomes, while 35% mapped to the short arms. The distal regions of chromosome arms showed higher numbers of loci than the proximal regions, with the exception of 4DL. This study confirmed the complex structure of chromosome 4A that contains two reciprocal translocations and two inversions, previously identified. An additional inversion in the centromeric region of 4A was revealed. A consensus map for homoeologous group 4 was developed from 119 ESTs unique to group 4. Forty-nine percent of these ESTs were found to be homoologous to sequences on rice chromosome 3, 12% had matches with sequences on other rice chromosomes, and 39% had no matches with rice sequences at all. Limited homology was found between wheat ESTs on homoeologous group 4 and the Arabidopsis genome. Forty-two percent of the homoeologous group 4 ESTs could be classified into functional categories on the basis of blastX searches against all protein databases. (shrink)

The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chromosome bin map of wheat homoeologous group 2 chromosomes to determine the distribution of ESTs, construct a consensus map of group 2 ESTs, investigate synteny, examine patterns of duplication, and assess the colinearity with rice (...) of ESTs assigned to the group 2 consensus bin map. A total of 2600 loci generated from 1110 ESTs were mapped to group 2 chromosomes by Southern hybridization onto wheat aneuploid chromosome and deletion stocks. A consensus map was constructed of 552 ESTs mapping to more than one group 2 chromosome. Regions of high gene density in distal bins and low gene density in proximal bins were found. Two interstitial gene-rich islands flanked by relatively gene-poor regions on both the short and long arms and having good synteny with rice were discovered. The map locations of two ESTs indicated the possible presence of a small pericentric inversion on chromosome 2B. Wheat chromosome group 2 was shown to share syntenous blocks with rice chromosomes 4 and 7. (shrink)

Kittle's recent paper brings into focus two interesting aspects of dispositions and employs them in an attempt to distinguish between cases where dispositions are subject to intrinsic interferers and cases where not. But I will argue below that Kittle doesn’t succeed in this attempt. The upshot is that no such distinction is in sight, and this continues to be a troubling problem for those philosophers who uphold the possibility of intrinsic interferers with dispositions by insisting that, whilst some dispositions aren’t (...) subject to intrinsic interferers, others are. (shrink)

Elizabeth Prior claims that dispositional predicates are incomplete in the sense that they have more than one argument place. To back up this claim, she offers a number of arguments that involve such ordinary dispositional predicates as ‘fragile’, ‘soluble’, and so on. In this paper, I will first demonstrate that one of Prior’s arguments that ‘is fragile’ is an incomplete predicate is mistaken. This, however, does not immediately mean that Prior is wrong that ‘fragile’ is an incomplete predicate. On the (...) contrary, I maintain that she has offered another valid argument that does indeed establish the claim that ‘fragile’ is an incomplete predicate. I will argue further that Prior is right that ‘soluble’ is an incomplete predicate. Then does this mean that all dispositional predicates are incomplete? I don’t think so. I will suggest that there are complete dispositional predicates that have no more than one argument place. Finally, by relying on my discussion of the incompleteness of dispositional predicates, I will attempt to provide a better understanding of the context-dependence and intrinsic nature of dispositional ascriptions. (shrink)

Contents: Wisdoms of East and West; Method of Analysis; Table of Symbolic Numbers; The Three Columns; Application of Principles to History; Astrology; Twelve ...

IN the Sixteenth Satire, the first topic Juvenal takes up in detail is the impossibility of obtaining satisfactory legal redress from the praetorians. The account has two divisions: you will have a bad time yourself in the military court, and what friend will come to support you ?

Many personal identity theorists claim that persons are distinct from the animals that constitute them, but when combined with the plausible assumption that animals share the thoughts of the persons they constitute, this denial results in an excess of thinkers and a host of related problems. I consider a number of non-animalist solutions to these problems and argue that they fail. I argue further that satisfactory non-animalist solutions are not forthcoming and that in order to avoid these problems we ought (...) to affirm our identity with animals. I then discuss arguments to the effect that i) animalism faces its own problems of too many thinkers, arising from the non- identity of animals with thinking bodies and thinking body parts, and ii) that in order to avoid these problems we must deny not just that there are persons distinct from animals, but that there are bodies and body parts distinct from animals Once the second of these claims is granted, there is a short further step to the conclusion that there are no such things as body parts, and from there there is a direct route to eliminative animalism. Eliminative animalism denies not only that there are persons distinct from animals, but that there are any composite objects distinct from animals. This position has been gaining popularity recently, but I argue that we need not, and indeed should not, accept it. Although the problems of the thinking animal do commit us to animalism, the problems of thinking bodies and thinking body parts do not commit us to eliminate animalism. (shrink)

This research examines the extent to which similarities and differences exist in the codes of professional conduct of certified (chartered) accountants across the following countries: the United States, Taiwan, South Korea, Malaysia, Ontario (Canada), Australia, India, and Hong Kong. These eight countries exemplify some of the diversity in economic, political, legal, and cultural environments in which public accountants practice. The professional codes of ethics establish the ethical boundary parameters within which professional accountants must operate and they are a function of (...) these environments.The results of the study reveal that commonalities exist on some ethical rules indicating that some rules are indeed "culture free". Cross-country variations, however, exist as to the specificity and elaborateness of the rules. Such variations can be attributed to cultural and legal differences, as well as the length of time each professional organization has been in existence. An understanding of the similarities and differences in the codes is important to individuals who may work in these countries. Professional accountants involved in international business must understand the implications of the decisions they make in light of the ethical codes and moral values of their counterparts in foreign countries. After a discussion of the similarities and differences in the codes, the implications of these comparisons for accounting practice are discussed. (shrink)

Point-of-care testing (POCT) is a sensitive, specific and rapid form of testing for the presence of HIV antibodies. Post-exposure prophylaxis for HIV infection can reduce seroconversion rates by up to 80%. Needlestick injuries are the second commonest cause of occupational injury in the NHS and 20% of these occur during operations. In the NHS, in order to protect staff and patients from the risk of bloodborne viruses such as HIV, it is mandatory to report such injuries; however, numerous studies have (...) shown that many groups, particularly doctors, are reluctant to do so. This article outlines the arguments for and against the introduction of preoperatively seeking consent from patients to have their blood tested for HIV via POCT in order to improve the reporting rates of needlestick injuries incurred during surgery and to protect staff from infection. (shrink)

What kind of properties are moral qualities, such as rightness, badness, etc? Some ethicists doubt that there are any such properties; they maintain that thinking that something is morally wrong (for example) is comparable to thinking that something is a unicorn or a ghost. These "moral error theorists" argue that the world simply does not contain the kind of properties or objects necessary to render our moral judgments true. This radical form of moral skepticism was championed by the philosopher John (...) Mackie (1917-1981). This anthology is a collection of philosophical essays critically examining Mackie’s view. (shrink)